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셀랑크 10mg

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세균성 물

유리 (1) 30 ml 세균성 물
자격을 갖춘 주문이 있습니다$ 500 USD. (캡슐 제품, 미용 펩티드, 프로모션 코드 및 배송 제외)

셀랑크Tuftsin의 짧은 합성 아날로그입니다. 그것은 심오한 반점 속성을 가지고 있습니다. Selank는 또한 기억과 학습을 향상시키고 통증 인식에 유익한 영향을 미치는 것으로 나타났습니다.
제품 사용 :이 제품은 연구 화학 물질로만 의도 된 것입니다.이 명칭은 시험 관내 시험 및 실험실 실험에만 연구 화학 물질을 엄격하게 사용할 수있게한다. 이 웹 사이트에서 제공되는 모든 제품 정보는 교육 목적으로 만 사용됩니다. 인간이나 동물에 어떤 종류의 신체적으로 소개되는 것은 법에 의해 엄격히 금지되어 있습니다. 이 제품은 라이센스가 부여 된 자격을 갖춘 전문가 만 처리해야합니다. 이 제품은 약물, 음식 또는 화장품이 아니며 약물, 음식 또는 화장품으로 잘못 브랜드화되거나 잘못 사용되거나 오해가되지 않을 수 있습니다.

Selank 개요

Selank, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life. Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.

셀랑크 구조

Selank Structure 순서: thr-lys-pro-arg-pro-gly-pro분자식: c33시간57N11영형9 분자량: 751.887 g/molPubchem Cid: 11765600CAS 번호: 129954-34-3동의어: Selanc Source:Pubch

셀랑크 연구

GABA Neurotransmitter와 관련된 유전자에 기초한 Selank 불안 효과

Anastasiya Volkova 박사에게 공인러시아의 분자 유전학 연구소, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia. Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1]. 이러한 수용체 친화력의 변화는 셀 랭크가 벤조디아제핀 및 다른 GABA 수용체 작용제와 상승적 인 이유를 설명 할 가능성이있다.Selank로 처리 된 쥐에서 시간의 기능으로서 유전자 발현의 변화.Changes in gene expression as a function of time in rats treated with Selank. Source:PubMed쥐의 연구에 따르면 Selank와 Benzodiazepines는 단독으로 사용될 때 불안, 특히 일반화 된 불안 장애에 유사한 영향을 미칩니다. Selank는 높은 수준의 불안을 줄이려고 시도 할 때 Benzodiazepines에 비해 약간의 이점을 보유 할 수 있지만, 두 치료의 조합은 예측할 수없는 만성 온화한 스트레스를 치료하는 데 가장 적합한 것으로 보입니다.[2]. The effects that Selank has on GABA receptors may be modulated, to some degree, by the peptide’s effect on enkephalin degradation. Testing indicates that people with anxiety and phobic disorders demonstrate increased enkephalinase activity in the blood during generalized anxiety and, as a result, the enkephalins they produce have shorter half-lives[3]. Enkephalinase 억제를 통한 Enkephalin의 분해를 방지함으로써 Selank는이 효소 경로를 재설정하고 신체의 자연 불안 완화 펩티드를 보호하는 데 도움이 될 수 있습니다. 불안에 취약한 마우스 연구[4].

셀랑크와 면역 체계

우울증 환자의 연구에 따르면 Selank는 염증성 사이토 카인 IL-6의 생산을 담당하는 유전자를 억제 할 수 있습니다. 흥미롭게 도이 효과는 우울증 환자에서만 볼 수 있으며 건강한 개인에서는 일어나지 않는 것으로 보입니다.[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression. When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins. Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops. Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].

기억과 학습에 대한 Selank 연구

There has long been an association between anxiety and learning/memory. The correlation is a negative one, with increased anxiety leading to decreased ability to recall memories or store new information. Traditional anxiety treatments can reduce this effect, as can Selank, but Selank appears to do more than simply reduce the impact of anxiety on cognitive function. There is good reason to believe that Selank actually boosts cognition directly. Research in rats trains with food rewards and injected with either saline or Selank has shown that Selank boosts memory trace stability and thus enhances the memory storage process[9]. It is important to note that this benefit was seen regardless of the anxiety levels of the rats, indicating that the peptide has effects beyond its ability to simply reduce stress-related impairment of memory. It appears that Selank may alter memory by affecting the expression of a number of genes in the hippocampus. Research in rats shows changes in mRNA levels of 36 different genes after intranasal administration of Selank. Most of the genes encode proteins associated with the plasma membrane and may therefore modulate ion-dependent processes in learning and memory[10]. Though much research needs to be done to understand the mechanism by which Selank works to improve memory and learning, this research offers a tantalizing early clue to suggest that it alters the way neurons function in such a way that both forming and accessing memories is easier. Research even suggests that Selank can help to rescue memory and learning following damage to the brain. Rats treated with a neurotoxin and then Selank showed restored cognitive processes in at least one study. This effect appears to be related to an artificial inhibition of the catecholamine system in the brain by Selank[11]. Selank가 외상성 뇌 손상, 특히 출생 과정에서 발생하는 부상의 종류에 따라인지 기능이 어떻게 회복되거나 최소한 개선 될 수 있는지에 대해 밝히는 데 도움이되기를 희망합니다.

셀랑크 연구와 고통

Selank는 인간의 혈액에서 발견되는 효소를 억제함으로써 천연 엔케팔린의 분해를 줄이기 위해 행동 할 수 있습니다.[12]. Enkephalins are natural peptides that bind to opioid receptors and help to blunt the severity of pain. They also function in the human stress response and are found in high levels in the brain and adrenal glands. By reducing levels of enkephalins in the brain, Selank may help to blunt the normal stress response and the effects that it has on memory, learning, and concentration. Selank exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Selank for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Selank if you are a licensed researcher.

기사 저자

위의 문헌은 Dr. Logan, M.D. Dr. Logan이 연구, 편집 및 조직했습니다.사례 서부 예비 대학교 의과 대학그리고 B.S. 분자 생물학에서.

과학 저널 저자

Petr Slominsky 박사‘s 169 research works with 803 citations. 12 of those papers pertain to the examination of Selank’s diverse, multifaceted effects e.g. anxiety reduction, changes in the transcription profile of the hippocampus, and changes in expression of the genes for chemokines, cytokines, and their receptors. Dr. Slominsky is particularly interested in the epigenetic effects of Selank and other disease-state pathologies. Dr. Petr Slominskyis being referenced as one of the leading scientists involved in the research and development of Selank. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide.Dr. Petr Slominsky is listed in [7] under the referenced citations.

참조 인용

    A. Volkova et al., “Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission,” Front. Pharmacol., vol. 7, Feb. 2016. [PubMed] A. Kasian et al., “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats,” Behavioural Neurology, 2017. [Online]. Available:https://www.hindawi.com/journals/bn/2017/5091027/. A. A. Zozulya et al., “The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity,” Bull. Exp. Biol. Med., vol. 131, no. 4, pp. 315–317, Apr. 2001. [PubMed] O. Y. Sokolov, V. K. Meshavkin, N. V. Kost, and A. A. Zozulya, “Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions,” Bull. Exp. Biol. Med. [PubMed] O. N. Uchakina et al., “[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders],” Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, vol. 108, no. 5, pp. 71–75, 2008. [PubMed] A. A. Zozulia et al., “[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia],” Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, vol. 108, no. 4, pp. 38–48, 2008. [PubMed] T. Kolomin, M. Shadrina, L. Andreeva, P. Slominsky, S. Limborska, and N. Myasoedov, “Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank,” Regul. Pept., vol. 170, no. 1–3, pp. 18–23, Oct. 2011. [PubMed] T. I. Agapova et al., “[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex],” Mol. Genet. Mikrobiol. Virusol., no. 3, pp. 28–32, 2008. [PubMed] T. P. Semenova, I. I. Kozlovskiĭ, N. M. Zakharova, and M. M. Kozlovskaia, “[Experimental optimization of learning and memory processes by selank],” Eksp. Klin. Farmakol., vol. 73, no. 8, pp. 2–5, Aug. 2010. [PubMed] T. A. Kolomin et al., “[c],” Zh. Vyssh. Nerv. Deiat. Im. I. P. Pavlova, vol. 63, no. 3, pp. 365–374, Jun. 2013. T. P. Semenova, M. M. Kozlovskaya, N. M. Zakharova, I. I. Kozlovskii, and A. V. Zuikov, “Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny,” Bull. Exp. Biol. Med., vol. 144, no. [PubMed] N. V. Kost et al., “[Semax and selank inhibit the enkephalin-degrading enzymes from human serum]],” Bioorg. Khim., vol. 27, no. 3, pp. 180–183, Jun. 2001. [Springer]
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